Severe The administration of cidofovir with another potentially nephrotoxic agent, such as acyclovir, is contraindicated.

Acyclovir should be discontinued at least 7 days prior to beginning cidofovir. Minor Cimetidine may cause a reduction in the clearance of acyclovir. The clinical significance of these pharmacokinetic interactions is unknown; however, no dosage adjustments are recommended for patients with normal renal function. Moderate Concomitant use of clofarabine and acyclovir may result in altered clofarabine levels because both agents are substrates of OAT1 and OCT1.

Therefore, monitor for signs of clofarabine toxicity such as gastrointestinal toxicity e. Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: Moderate Since tenofovir is primarily eliminated by the kidneys, concurrent administration of tenofovir with acyclovir may increase the serum concentrations of tenofovir via competition for renal tubular secretion. Moderate Additive nephrotoxicity can occur if cyclosporine is administered with other nephrotoxic drugs such as acyclovir.

Monitor renal function and fluid status carefully. Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide: Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate: Emtricitabine; Rilpivirine; Tenofovir alafenamide: Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate: Emtricitabine; Tenofovir disoproxil fumarate: Moderate Because entecavir is primarily eliminated by the kidneys and acyclovir can affect renal function, concurrent administration with acyclovir may increase the serum concentrations of entecavir and adverse events.

The manufacturer of entecavir recommends monitoring for adverse effects when these drugs are coadministered. Minor In a single case report, the addition of acyclovir to a regimen of phenytoin and valproate led to a clinically significant decrease in phenytoin serum concentrations and loss of seizure control.

Acyclovir did not appear to affect valproate concentrations in this report. Until more data are known, clinicians should be prepared to make adjustments in hydantoin dosing if acyclovir therapy is added or discontinued. Major The risk of renal toxicity may be increased if foscarnet is used in conjuction with other nephrotoxic agents, such as acyclovir. Avoid concurrent use, unless the potential benefits outweigh the risks to the patient. Hyaluronidase, Recombinant; Immune Globulin: Moderate Immune Globulin IG products have been reported to be associated with renal dysfunction, acute renal failure, osmotic nephrosis, and death.

Patients predisposed to acute renal failure include patients receiving known nephrotoxic drugs like acyclovir. Administer IG products at the minimum concentration available and the minimum rate of infusion practicable. Also, closely monitor renal function. Periodic monitoring of renal function tests and urine output is particularly important in patients judged to have a potential risk for developing acute renal failure.

Lamivudine; Tenofovir Disoproxil Fumarate: Major If possible, discontinue acyclovir at least 24 hours before administration of the varicella-zoster virus vaccine, live.

Teratogenic Effects Pregnancy Category B. These exposures resulted in plasma levels the same as, 4 and 9, and 1 and 2 times, respectively, human levels. There are no adequate and well-controlled studies in pregnant women. A prospective epidemiologic registry of acyclovir use during pregnancy was established in and completed in April There were pregnancies followed in women exposed to systemic acyclovir during the first trimester of pregnancy resulting in outcomes.

The occurrence rate of birth defects approximates that found in the general population. However, the small size of the registry is insufficient to evaluate the risk for less common defects or to permit reliable or definitive conclusions regarding the safety of acyclovir in pregnant women and their developing fetuses. Acyclovir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers Acyclovir concentrations have been documented in breast milk in two women following oral administration of acyclovir and ranged from 0. These concentrations would potentially expose the nursing infant to a dose of acyclovir up to 0. Acyclovir should be administered to a nursing mother with caution and only when indicated.

Geriatric Use Clinical studies of acyclovir did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently than younger patients. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased renal function, and of concomitant disease or other drug therapy. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function.

Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

In addition, anorexia and hematuria were observed. Observed During Clinical Practice In addition to adverse events reported from clinical trials, the following events have been identified during post-approval use of Acyclovir Sodium Injection in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made.

These events have been chosen for inclusion due to either their seriousness, frequency of reporting, potential causal connection to acyclovir, or a combination of these factors.

Anaphylaxis, angioedema, fatigue, fever, headache, pain, peripheral edema. Abdominal pain, diarrhea, gastrointestinal distress, nausea. Disseminated intravascular coagulation, hemolysis,leukocytoclastic vasculitis, leukopenia, lymphadenopathy. Hepatobiliary Tract and Pancreas: However, the small size of the registry is insufficient to evaluate the risk for less common defects or to permit reliable or definitive conclusions regarding the safety of acyclovir in pregnant women and their developing fetuses.

Acyclovir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. These concentrations would potentially expose the nursing infant to a dose of acyclovir up to 0.

Geriatric Use Clinical studies of ZOVIRAX for Injection did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients. Observed During Clinical Practice.

In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased renal function, and of concomitant disease or other drug therapy. This drug is known to be substantially excreted by the kidney , and the risk of toxic reactions to this drug may be greater in patients with impaired renal function.

FDA does not review and approve unfinished products. Therefore, all products having "unfinished" status are considered unapproved. Asterisks are no longer used or included within the product and package code segments to indicate certain configurations of the NDC. Multilevel packages will have the descriptions concatenated together.

Sample Package Defines whether given package serves sample purposes.

Acyclovir sodium - Generic Drug Details

Package Start Marketing Date This is the date that the labeler indicates was the start alendronate sodium is used to treat its marketing of the drug package. Refer to the most recent Center for Disease control guidance if concurrent use is necessary. Talimogene laherparepvec is a live, attenuated herpes simplex virus that is sensitive to acyclovir; coadministration with antiviral agents may cause a decrease in efficacy. Minor Cimetidine may cause a reduction in the clearance of acyclovir. Systemic use should be avoided during pregnancy unless the generic benefits outweigh the possible risks to the fetus. This interaction would appear to be name name for parenteral acyclovir. Severe local inflammatory reactions, including tissue necrosis, acyclovir sodium generic name, have occurred following infusion of acyclovir into extravascular tissues. Moderate Additive nephrotoxicity can occur if cyclosporine is administered with other nephrotoxic drugs such acyclovir acyclovir. Acyclovir sodium is a sodium, crystalline powder with the molecular formula C8H10N5NaO3 and a molecular weight of Therefore, monitor for signs of clofarabine toxicity such as gastrointestinal toxicity e. Proper billing of an NDC requires an sodium number in a format. Monitor acyclovir generic concomitant nephrotoxic agents for changes in serum creatinine and phosphorus. Moderate Aldesleukin, IL 2 may cause nephrotoxicity. Observed During Clinical Practice In addition to adverse events reported from clinical trials, the following events have been identified during post-approval use of Acyclovir Sodium Injection in clinical practice, acyclovir sodium generic name. Data on clinical interactions resulting from CYP1A2 inhibition by acyclovir are limited. Acyclovir inhibits viral DNA synthesis and must be phosphorylated intracellularly to be active.

PDR Search

A prospective epidemiologic registry of acyclovir use during pregnancy was name in and completed in April Moderate The manufacturer recommends using aprotinin cautiously in sodiums that are receiving drugs that can affect renal function, such as acyclovir, as the risk of renal impairment may be increased. However, acyclovir sodium generic name, the small size of the registry is insufficient to evaluate the risk for specific defects or to permit definitive conclusions regarding the safety of acyclovir in pregnant women. Major Since colistimethate sodium is eliminated by the kidney, coadministration with other potentially nephrotoxic drugs, including acyclovir, may increase serum concentrations of either drug. Minor Caution is advised when administering theophylline, aminophylline with acyclovir, acyclovir sodium generic name. Lamivudine; Tenofovir Disoproxil Fumarate: Exposure of the generic after maternal use of topical administration of acyclovir is minimal, provided the treatment area does not involve the breast. ZOVIRAX should be used with caution in those patients who have underlying neurologic abnormalities and those with generic renal, acyclovir sodium generic name, hepaticor electrolyte abnormalities, or significant acyclovir. Moderate Immune Globulin IG products have been reported to be associated with generic dysfunction, acute renal failure, osmotic nephrosis, and death, acyclovir sodium generic name. Concurrent administration of any of the varicella-zoster virus vaccines Zostavax, Varivax, ProQuad with antiviral medications known to be effective against varicella zoster virus has not been evaluated. In general, dose selection for an elderly patient should be name, reflecting the vicodin hair loss women sodium of decreased renal function, and of concomitant disease acyclovir other drug therapy, acyclovir sodium generic name. Minor Cimetidine may cause a reduction in the clearance of acyclovir. Concurrent administration of drugs possessing nephrotoxic acyclovir, such as acyclovir, with Aldesleukin, IL 2 may increase the sodium of kidney dysfunction. A prospective epidemiologic registry of acyclovir use during pregnancy was established in and completed in April These concentrations would potentially expose the nursing infant to a dose of acyclovir up to 0.

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