To make sure this medicine is safe for you, tell your doctor if you have ever had: Levaquin may cause swelling or tearing of a tendon the fiber that connects bones to muscles in the body , especially in the Achilles' tendon of the heel. This can happen during treatment or up to several months after you stop taking Levaquin.
Tendon problems may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant. Do not give this medicine to a child without medical advice. Tendon and joint problems may be more likely in a child taking levofloxacin. It is not known whether this medicine will harm an unborn baby.
Tell your doctor if you are pregnant or plan to become pregnant. Levofloxacin can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine. How should I take Levaquin? Take Levaquin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take Levaquin with water, at the same time each day. These include anaphylaxis, hepatotoxicity, central nervous system effects including seizures and psychiatric effects, prolongation of the QT interval , blood glucose disturbances, and photosensitivity , among others.
The most common adverse reactions leading to discontinuation were gastrointestinal, including nausea, vomiting, and constipation. Fluoroquinoline administration may be associated with the acquisition and outgrowth of a particularly virulent Clostridium strain. Levofloxacin is not efficiently removed by hemodialysis or peritoneal dialysis.
With the DNA not being separated, the process is stopped, and the bacterium cannot divide. DNA gyrase, on the other hand, is responsible for supercoiling the DNA, so that it will fit in the newly formed cells. If patients need to be outdoors when taking fluoroquinolones, they should wear loose-fitting clothes that protect skin from sun exposure and discuss other sun protection measures with their physician.
If a sunburn like reaction or skin eruption occurs, patients should contact their physician. Drug Interactions With Insulin, Oral Hypoglycemic Agents, And Warfarin Patients should be informed that if they are diabetic and are being treated with insulin or an oral hypoglycemic agent and a hypoglycemic reaction occurs, they should discontinue Levofloxacin and consult a physician.
Patients should be informed that concurrent administration of warfarin and Levofloxacin has been associated with increases of the International Normalized Ratio INR or prothrombin time and clinical episodes of bleeding. Patients should notify their physician if they are taking warfarin, be monitored for evidence of bleeding, and also have their anticoagulation tests closely monitored while taking warfarin concomitantly.
Plague And Anthrax Studies Patients given Levofloxacin for these conditions should be informed that efficacy studies could not be conducted in humans for ethical and feasibility reasons. Therefore, approval for these conditions was based on efficacy studies conducted in animals. Levofloxacin did not shorten the time to tumor development of UV-induced skin tumors in hairless albino Skh-1 mice at any levofloxacin dose level and was therefore not photo-carcinogenic under conditions of this study.
By comparison, dermal levofloxacin concentrations in human subjects receiving mg of Levofloxacin averaged approximately Levofloxacin was not mutagenic in the following assays: Ames bacterial mutation assay S. There are, however, no adequate and well-controlled studies in pregnant women.
Levofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Nursing Mothers Based on data on other fluoroquinolones and very limited data on Levofloxacin, it can be presumed that levofloxacin will be excreted in human milk.
Because of the potential for serious adverse reactions from Levofloxacin in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric Use Quinolones, including levofloxacin, cause arthropathy and osteochondrosis in juvenile animals of several species.
Inhalational Anthrax Post-Exposure Levofloxacin is indicated in pediatric patients 6 months of age and older, for inhalational anthrax postexposure. The risk-benefit assessment indicates that administration of levofloxacin to pediatric patients is appropriate. Plague Levofloxacin is indicated in pediatric patients, 6 months of age and older, for treatment of plague, including pneumonic and septicemic plague due to Yersinia pestis Y.
Efficacy studies of Levofloxacin could not be conducted in humans with pneumonic plague for ethical and feasibility reasons. The milk levels fell with an estimated half-life of 7 hours.
Traces of levofloxacin were still detectable in breastmilk 65 hours after the dose. The authors calculated that an exclusively breastfed infant whose mother was taking mg daily would receive 1. Relevant published information was not found as of the revision date. Effects in Breastfed Infants Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk Relevant published information was not found as of the revision date. The effects of a fluoroquinolone on the growth and development of infants.
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