This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you. Take as directed Simvastatin is used for long-term treatment. If you don't take it on schedule: Not taking simvastatin every day, skipping days, or taking doses at different times of the day may also increase your risk for high cholesterol levels, heart attack, or stroke. If you miss a dose: If you miss a dose, take the next dose as scheduled.
How can I tell if the drug is working: Your cholesterol and triglyceride levels should be within healthy levels while taking it. Keep these considerations in mind if your doctor prescribes simvastatin for you. General You can take simvastatin with or without food.
Taking it with food may reduce nausea. Take simvastatin in the evening to maximize its effects. The increased incidence of thyroid neoplasms appears to be consistent with findings from other statins. These treatment levels represented plasma drug levels AUC of approximately 7 and 15 times males and 22 and 25 times females the mean human plasma drug exposure after an 80 milligram daily dose.
No evidence of mutagenicity was observed in a microbial mutagenicity Ames test with or without rat or mouse liver metabolic activation. In addition, no evidence of damage to genetic material was noted in an in vitro alkaline elution assay using rat hepatocytes, a V mammalian cell forward mutation study, an in vitro chromosome aberration study in CHO cells, or an in vivo chromosomal aberration assay in mouse bone marrow. No microscopic changes were observed in the testes of rats from either study.
The clinical significance of these findings is unclear. Lipid lowering drugs offer no benefit during pregnancy, because cholesterol and cholesterol derivatives are needed for normal fetal development. Atherosclerosis is a chronic process, and discontinuation of lipid-lowering drugs during pregnancy should have little impact on long-term outcomes of primary hypercholesterolemia therapy. There are no adequate and well-controlled studies of use with ZOCOR during pregnancy; however, there are rare reports of congenital anomalies in infants exposed to statins in utero.
Animal reproduction studies of simvastatin in rats and rabbits showed no evidence of teratogenicity. Serum cholesterol and triglycerides increase during normal pregnancy, and cholesterol or cholesterol derivatives are essential for fetal development.
Because statins decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, ZOCOR may cause fetal harm when administered to a pregnant woman. If ZOCOR is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. There are rare reports of congenital anomalies following intrauterine exposure to statins.
However, the study was only able to exclude a 3- to 4-fold increased risk of congenital anomalies over the background rate. However, in studies with another structurally-related statin, skeletal malformations were observed in rats and mice. How to take Simvador.
Simvador has not been studied in children under the age of 10 years. For more information, talk to your doctor. Driving and using machines Simvador has no known ef fect on the ability to drive or operate machines. Simvastatin can cause dizziness so make sure you are not af fected before you drive or use machines. Important information about some of the ingredients of Simvador Simvador tablets contain a sugar called lactose.
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product. How to take Simvador Always take simvador exactly as your doctor has told you. If you are not sure, check with your doctor or pharmacist.
Your dose will be decided by your doctor and will depend on the results of the blood tests. The dose you should take will be on the label at tached by your pharmacist. Swallow the medicine with plenty of water. Remember to keep to a low-fat diet and to take physical exercise. People with coronary heart disease CHD The usual dose is 20mg — 40mg which you should take in the evening. Your doctor may increase the dose you take every 4 weeks.
The ma ximum dose is 80mg. People with high levels of blood fats Hyperlipidaemia The usual starting dose is 10mg taken in the evening. People with hereditary high cholesterol homozygous familial hypercholesterolaemia The usual dose is 40mg taken in the evening.
Your doctor may ask you to take 80mg each day in three doses through the day 20mg, 20mg and 40mg. This 80mg dose is only for patients who have very high levels of cholesterol in their blood or are at a high risk of developing heart problems who have not reached their cholesterol goal on lower doses. Dosage is based on your medical condition, response to treatment, age, and other medications you may be taking.
Be sure to tell your doctor and pharmacist about all the products you use including prescription drugs , nonprescription drugs, and herbal products. Chinese patients taking niacin may require lower doses of simvastatin. Ask your doctor for more details. The usual maximum dose for this medication is 40 milligrams a day. If you have been instructed by your doctor to take more than 40 milligrams, continue on that same dose.
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© Copyright 2017 Simvastatin 20 mg bivirkninger *** Simvastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs known as "statins." It works by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol ..