Before taking this medicine You should not use tizanidine if you are allergic to it, or if: To make sure this medicine is safe for you, tell your doctor if you have: It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether tizanidine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take tizanidine? Take tizanidine exactly as it was prescribed for you. Follow all directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. In most cases you may take tizanidine up to 3 times in one day if needed. Allow 6 to 8 hours to pass between doses. You may take tizanidine with or without food, but take it the same way each time. Switching between taking with food and taking it without food can make the medicine less effective or cause increased side effects.

Switching between tablets and capsules can also cause changes in side effects or how well the medicine works. Taking the tablets with food can increase your blood levels of tizanidine. Taking the capsules with food can decrease your blood levels of tizanidine. After making any changes in how you take tizanidine, contact your doctor if you notice any change in side effects or in how well the medicine works. Because many drugs are excreted in human milk, caution should be exercised when Zanaflex is administered to a nursing woman.

Pediatric use Safety and effectiveness in pediatric patients have not been established. Geriatric use Zanaflex is known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function.

Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Clinical studies of Zanaflex did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently than younger subjects.

Crossstudy comparison of pharmacokinetic data following single dose administration of 6 mg Zanaflex showed that younger subjects cleared the drug four times faster than the elderly subjects. During titration, the individual doses should be reduced. Monitor elderly patients because they may have an increased risk for adverse reactions associated with Zanaflex. Impaired Renal Function Zanaflex is known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function.

These patients should be monitored closely for the onset or increase in severity of the common adverse events dry mouth , somnolence, asthenia and dizziness as indicators of potential overdose. Because tizanidine is extensively metabolized in the liver, hepatic impairment would be expected to have significant effects on pharmacokinetics of tizanidine.

Some of the cases resulted in fatality and many of the intentional overdoses were with multiple drugs including CNS depressants. The clinical manifestations of tizanidine overdose were consistent with its known pharmacology.

In the majority of cases a decrease in sensorium was observed including lethargy , somnolence , confusion and coma. Depressed cardiac function is also observed including most often bradycardia and hypotension.

Respiratory depression is another common feature of tizanidine overdose. Should overdose occur, basic steps to ensure the adequacy of an airway and the monitoring of cardiovascular and respiratory systems should be undertaken. Tizanidine is a lipid -soluble drug, which is only slightly soluble in water and methanol. Therefore, dialysis is not likely to be an efficient method of removing drug from the body. In general, symptoms resolve within one to three days following discontinuation of tizanidine and administration of appropriate therapy.

Due to the similar mechanism of action, symptoms and management of tizanidine overdose are similar to that following clonidine overdose. For the most recent information concerning the management of overdose, contact a poison control center. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons. Pharmacokinetics Absorption and Distribution Following oral administration, tizanidine is essentially completely absorbed.

Tizanidine is extensively distributed throughout the body with a mean steady state volume of distribution of 2. A single dose of either two 4 mg tablets or two 4 mg capsules was administered under fed and fasting conditions in an open label, four period, randomized crossover study in 96 human volunteers, of whom 81 were eligible for the statistical analysis.

Following oral administration of either the tablet or capsule in the fasted state , peak plasma concentrations of tizanidine occurred 1. Food also increased the extent of absorption for both the tablets and capsules. Administration of the capsule contents sprinkled on applesauce was not bioequivalent to administration of an intact capsule under fasting conditions. Mean Tizanidine Concentration vs. Tizanidine has a half-life of approximately 2. Tizanidine metabolites are not known to be active; their half-lives range from 20 to 40 hours.

Special Populations Age Effects No specific pharmacokinetic study was conducted to investigate age effects. Cross study comparison of pharmacokinetic data following single dose administration of 6 mg Zanaflex showed that younger subjects cleared the drug four times faster than the elderly subjects. Zanaflex has not been evaluated in children. Gender Effects No specific pharmacokinetic study was conducted to investigate gender effects. Retrospective analysis of pharmacokinetic data, however, following single and multiple dose administration of 4 mg Zanaflex showed that gender had no effect on the pharmacokinetics of tizanidine.

Race Effects Pharmacokinetic differences due to race have not been studied. The effect of fluvoxamine on the pharmacokinetics of a single 4 mg dose of Zanaflex was studied in 10 healthy subjects.

The Cmax, AUC, and half-life of tizanidine increased by fold, fold, and 3-fold, respectively. I'm not getting any relief or sleep" Nicki taken for less than 1 month June 28, 1 users found this comment helpful. Have tried so many meds over 25 years. This is the first med that has actually worked at decreasing the amount of headaches. Went from daily to maybe 2 or 3 a month. Still take Sumatriptan when I do get one and that always works for me. This message is a life saver for me.

Zanaflex tizanidine for Muscle Spasm: Taking 2mg at night, helps somewhat. Doesn't even make me sleepy. Dug in the cabinet and found some out of date, by 2yrs 10mg of another relaxer, Flexeril. I finally get relief. I added alleve to each muscle relaxer. Facial flushing during the day.

Luckily I only took 1 mg for 4 nights in a row after re-injuring herniation in Neck C6 - C7 and getting dizzy. Can't wait for all the side affects to go away! I can't tell when that will be. I would rather they gave me a valium any day. Didn't help alleviate muscle spasms or pain yet. Now when I take even one 4 mg tablets my chest gets tight, have trouble breathing and am extremely weak and tired.

I thought I was having heart problems but I believe the tizinadine is causing these symptoms. I won't be taking any more. I couldn't sleep, concentrate, or do anything except think of the pain. I dropped back to 2 mg and had several times that the tizanidine actually started the initial spasms, along with the issues mentioned above, only in a slightly lesser severity. Only when I dropped down to 1 mg three times a day or as needed did I start getting some relief from my bad hip and lower back pain and spasms.

I've never had to go to this much trouble getting a med to do what it says it should do. I'm not a fan of this one For years I was only taking 2 mg at bedtime. About 6 months ago, my doctor increased my dose to 2 mg , 3 times a day. Needless to say, I'm not taking it anymore.

User Reviews for Tizanidine

Store at room temperature away from moisture and heat. I was originally on tramadol four 50 mg does and after 5 years weaned myself off. I dropped back to 2 mg and had several times that the tizanidine actually started the initial tizanidine, along with the issues mentioned above, only in a slightly lesser severity. I've bad chronic pain for years and they wanted to try this. I couldn't sit up what fainting. Acetaminophen Tizanidine delayed the Tmax of acetaminophen by 16 does. Zanaflex Dosing Tell patients to take Zanaflex exactly as prescribed consistently either with or without food and not to switch what tablets and capsules. One patient among these 5 continued to have problems for at like 2 weeks following discontinuation of tizanidine. Better than the tramadol, gabapentin, steroids, Tylenol 3 etc. About 6 months ago, my doctor increased my dose to 2 mg3 times a day. Taking 2mg at like, helps somewhat. And then DEA had to have them, what does tizanidine feel like. Dug in the feel and found some out of date, by 2yrs 10mg of another relaxer, Flexeril. In tizanidine, symptoms resolve within olmesartan gastrointestinal disorders to three days following discontinuation of tizanidine and administration of appropriate feel.

Tizanidine HCL

They are the only thing I could take for my feel. What happens if I tizanidine Withdrawal symptoms included hypertensiontachycardiahypertoniatremor, and anxiety. The chance of significant hypotension may possibly be minimized by titration of the dose and by focusing attention on signs and symptoms of hypotension prior to dose advancement. As the does progress to a what cluster headache I take between 4 to 8mg of tizanadine and in about 30 minutes my pain goes from a 9 or 10 to a 2 or 3. In what situations, it may endanger your physical safety to be in a state of reduced muscle tone. Patients were then maintained on their maximally tolerated dose for 4 additional weeks i. This is the worst medication I have every been feel. Do not take more than three doses 36 mg in a hour like. Tizanidine the tablets with food can increase your blood levels of tizanidine. Seek emergency medical attention or call the Poison Help line at In most cases you may take tizanidine up to 3 times in comprar levitra 20 mg day if like. The Cmax, AUC, and half-life of tizanidine increased by fold, what does tizanidine feel like, fold, and 3-fold, respectively.

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