Severe colitis may result in death. Studies indicate a toxin s produced by Clostridia is one primary cause of antibiotic-associated colitis. The colitis is usually characterized by severe persistent diarrhea and severe abdominal cramps and may be associated with the passage of blood and mucus. Stool cultures for Clostridium difficileand stool assay for C. Concomitant topical acne therapy should be used with caution since a possible cumulative irritancy effect may occur, especially with the use of peeling, desquamating, or abrasive agents.
If irritation or dermatitis occurs, clindamycin should be discontinued. If contact occurs, rinse thoroughly with water. Adverse Reactions Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Abdominal pain and gastrointestinal disturbances, as well as gram-negative folliculitis, have also been reported in association with the use of topical formulations of clindamycin. Orally and parenterally administered clindamycin have been associated with severe colitis, which may end fatally.
If clindamycin foam is swallowed, call a doctor or poison control center right away. This medicine may catch on fire. Do not use near an open flame or while smoking. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using clindamycin foam while you are pregnant. Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby. How is this medicine Clindamycin Foam best taken?
Use clindamycin foam as ordered by your doctor. Read all information given to you. Follow all instructions closely. Follow how to use as you have been told by the doctor or read the package insert. To gain the most benefit, do not miss doses. Use as you have been told, even if your signs get better. If it is almost time for your next dose, wait until then to apply the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at Overdose symptoms include bloody or watery diarrhea, which may result if you absorb this medicine through your skin by applying too much. Do not use other medicated skin products unless your doctor has told you to. Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.
Avoid getting this medication in your eyes, nose, mouth, rectum, or vagina. If this does happen, rinse with water. Do not use clindamycin topical on sunburned, windburned, dry, chapped, irritated, or broken skin. Do not smoke while using clindamycin topical foam, or immediately after applying it. The contents of the foam canister are flammable. Before using clindamycin topical, tell your doctor if you are using any of the following drugs: This list is not complete and other drugs may interact with clindamycin topical.
Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Concomitant topical acne therapy should be used with caution since a possible cumulative irritancy effect may occur, especially with the use of peeling, desquamating, or abrasive agents.
If irritation or dermatitis occurs, clindamycin should be discontinued. If contact occurs, rinse thoroughly with water. Patients should be advised to discontinue use if excessive irritancy or dermatitis occur. The daily doses used in this study were approximately 3 and 15 times higher than the human dose of clindamycin phosphate from 5 milliliters of EVOCLIN Foam, assuming complete absorption and based on a body surface area comparison.
No significant increase in tumors was noted in the treated animals.
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